Identification of Critical Residues of Linear B Cell Epitope on Goodpasture Autoantigen
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چکیده
منابع مشابه
Identification of Critical Residues of Linear B Cell Epitope on Goodpasture Autoantigen
BACKGROUND The autoantigen of anti-glomerular basement membrane (GBM) disease has been identified as the non-collagenous domain 1 of α3 chain of type IV collagen, α3(IV)NC1. Our previous study revealed a peptide on α3(IV)NC1 as a major linear epitope for B cells and potentially nephrogenic, designated as P14 (α3129-150). This peptide has also been proven to be the epitope of auto-reactive T cel...
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Antibodies against linear epitopes on the Goodpasture autoantigen and kidney injury.
BACKGROUND AND OBJECTIVES Linear epitopes on the Goodpasture autoantigen involved in human anti-glomerular basement membrane (GBM) disease are not fully defined. This study investigated the linear epitopes recognized by circulating antibodies in anti-GBM patients, aiming to identify the potential nephrogenic linear epitopes and their clinical significance. DESIGN, SETTING, PARTICIPANTS, & MEA...
متن کاملRapid B Cell Linear Epitope Mapping
Conformational epitopes are thought to form the majority of strong antibody binding epitopes on most proteins. However numerous conformational epitopes may also be recognizable as linear epitopes, although with lower affinity. Linear B cell epitopes typically vary from 5 to 20 amino acids in length. If the antibody-binding region of the protein is unknown, an overlapping peptide library can be ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0123277